Stability of dilute solutions of gentamicin and tobramycin.
نویسندگان
چکیده
Dilution of sera containing gentamicin or tobramycin in glass containers results in substantial adsorption of the antibiotic to the surface of the container, which can be prevented if acidic or basic solutions are used to dilute such sera. We describe protocols for radioimmunoassays of gentamicin and tobramycin that include solutions and containers that obviate this problem.
منابع مشابه
Stability of Gentamicin, Tobramycin, and Amikacin in Combination with Four ,-Lactam Antibiotics
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متن کاملStability of Gentamicin, Tobramycin, and Amikacin in Combination with Four ,-Lactam Antibiotics
The stability of the aminoglycosides gentamicin, tobramycin, and amikacin stored in combination with carbenicillin, piperacillin, cefotaxime, and moxalactam was evaluated at four temperatures (25, 4, -8, and -70°C) over a 3-week period. Amikacin was the most stable of the aminoglycosides and demonstrated no loss of activity when stored with either carbenicillin or piperacillin. Gentamicin and t...
متن کاملStability of gentamicin, tobramycin, and amikacin in combination with four beta-lactam antibiotics.
The stability of the aminoglycosides gentamicin, tobramycin, and amikacin stored in combination with carbenicillin, piperacillin, cefotaxime, and moxalactam was evaluated at four temperatures (25, 4, -8, and -70 degrees C) over a 3-week period. Amikacin was the most stable of the aminoglycosides and demonstrated no loss of activity when stored with either carbenicillin or piperacillin. Gentamic...
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متن کاملKinetics of kill of bacterial conjunctivitis isolates with moxifloxacin, a fluoroquinolone, compared with the aminoglycosides tobramycin and gentamicin
PURPOSE To compare the kinetics and speed of kill of Streptococcus pneumoniae and Haemophilus influenzae on exposure to three topical ophthalmic antibiotic solutions. MATERIALS AND METHODS Bacterial conjunctivitis isolates of S. pneumoniae and H. influenzae were exposed to 1:1000 dilutions of moxifloxacin 0.5%, tobramycin 0.3%, gentamicin 0.3%, and water (control). At 15, 30, 60, 120, and 180...
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عنوان ژورنال:
- Clinical chemistry
دوره 25 2 شماره
صفحات -
تاریخ انتشار 1979